Low frequency subthalamic stimulation and event-related potentials in Parkinson disease

BackgroundHigh frequency (130 Hz) subthalamic Deep-Brain-Stimulation (STN-DBS) optimally improves cardinal motor symptoms in Parkinson disease (PD). Low stimulation frequencies (60–80 improve axial some patients and, according to preliminary evidences, may also have a beneficial effect on the cognitive component of planning.ObjectiveTo analyze configuration P300 cortical event-related auditory potentials (ERPs), reliable index attentive functions, at different STN-DBS PD patients.Methods12 underwent ERPs recordings using standard oddball paradigm with 60 Hz, 80 130 and OFF-stimulation, applied randomized double-blind sequence. analysis considered peak amplitude latency components midline electrode positions (Fz, Cz, Pz).ResultsP300 over Cz Pz electrodes significantly increased Hz compared OFF-stimulation. was increased, though lesser degree, Hz. No significant modifications were detected OFF-stimulation condition. did not change for any conditions tested.ConclusionsLow is associated minor conventional possibly suggesting that less interference processes patients.